Nasopharyngeal carcinoma in situ in nasopharyngeal carcinoma.

Nasopharyngeal carcinoma in situ in nasopharyngeal carcinoma.

AIMS To assess the presence of carcinoma in situ (CIS) in patients with nasopharyngeal carcinoma (NPC) and to see if the number of biopsy sites facilitates detection of CIS. METHODS Formalin fixed, paraffin wax embedded biopsy specimens (n = 285) from 187 patients with NPC in 1987 were studied for the presence of CIS as well as for the histological assessment of the subtype of CIS. RESULTS ...

بررسی میزان بیان آنزیم دایسر در نواحی in situ carcinoma در مقایسه با مناطق in vasive carcinoma در سرطان پستان

خلاصه : کارسینوم تهاجمی سینه پستان علت مرگ و میر حاصل از سرطان خانم ها در بسیاری از کشورها می باشد. این کارسینوم بدنبال کارسینوم در محل ایجاد می شود. در کارسینوم در محل سلول های توموری هنوز نتوانسته اند که از غشاء پایه عبور کنند. در عبور از مرحله کارسینوم در محل به مرحله تهاجمی، سلولهای سرطانی تغییرات مولکولی بسیاری پیدا میکنند که هنوز علت عده ای از آنها مشخص نشده است. در این مطالعه ما بررسی کر...

MicroRNAs in nasopharyngeal carcinoma

It is becoming increasingly evident that aberrantly expressed microRNAs (miRNAs) are responsible for a number of disease processes, including cancer initiation and progression. miRNAs have been implicated as key players in numerous neoplasms, including nasopharyngeal carcinoma (NPC). Functionally, deregulation of miRNAs that act either as tumour suppressors or oncogenes results in numerous canc...

Exosomes in Nasopharyngeal Carcinoma

Exosomes are nanosized (30-100nm) membrane microvesicles secreted through a complex cellular process. Exosomes contain a variety of bioactive molecules, such as proteins, microRNAs(miRNAs or miRs) and long non-coding RNAs (lncRNAs), playing an important role in the cell-to-cell substance transportation and signal transduction. Nasopharyngeal carcinoma-related exosomes (NPC-Exo) have been identi...

Epigenetics in Nasopharyngeal Carcinoma